Emit assay theophylline overdose

Biological principles of the procedure Theophylline assay is a competitive binding immunoenzymatic assay. An increase in the volume of distribution of theophylline, primarily due to reduction in plasma protein binding, occurs in premature neonates, patients with hepatic cirrhosis, uncorrected acidemia, the elderly and in women during the third trimester of pregnancy.

Toxicity vs therapeutic failure: You can call for any reason, 24 hours a day, 7 days a week. You can tailor each drug model to fit your patient population, or you can create your own models.

The theophyllines should be administered with caution in patients with severe cardiac disease, gastric ulcers, hyperthyroidism, renal or hepatic disease, severe hypoxia, or severe hypertension.

The high-performance liquid chromatography method needs skilled staff and more quantity of samples for detection than immunoassay. Tests that may be done include: Cardiac disease Patients with CHF have decreased theophylline clearance due to diminished blood flow to the liver.

Demethylation to 1-methylxanthine appears to be catalyzed either by cytochrome P 1A2 or a closely related cytochrome.

It has been suggested that the mechanism of action of charcoal in theopylline toxicity is the adsorption of theophylline in the lumen of the gut through direct dialysis of theophylline across the gut mucosal capillaries.

Neonatal and geriatric patients may have decreased clearances of theophylline and be more sensitive to its toxic effects. Trough or predose level Date Discuss these enzyme multiplied immunoassay technique definitions with the community: Such patients have not been well characterized.

In general, the common presentations of chlorpheniramine anticholinergic toxicity are dementia with mumbling speech, tachycardia, dry flushed skin, dilated pupils, myoclonus, slightly elevated temperature, urinary retention, decreased bowel sounds, seizures, and cardiac arrhythmias 3.

If fever is high and sustained, e. Tremors Home Care Seek medical help right away. This would double the rate of elimination of theophylline. Kinetics of intravenous administration, this treatment could be used in theophylline. The serum concen- Subject No.

We measured theophylline concentration in the serum of patients by CLIA and evaluated the method. Dietary intake of methylxanthines, caffeine in particular, decreases theophylline metabolism by acting as a substrate for metabolizing enzymes.

The volume of distribution in cats is reported to be 0. To ascertain an immediate provisional toxicological diagnosis in the emergency department is very challenging, especially when the patient presents with altered mental status.

Theophylline and beta-adrenergic blockers propranolol, etc. Since little theophylline is excreted unchanged in the urine and since active metabolites of theophylline i.

The Emit® II Plus Oxycodone Assay is used for the determination of oxycodone and its metabolite, oxymorphone, in human urine.

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Aug 10,  · Theophylline toxicity is a life-threatening toxidrome that can present to an emergency department. To ascertain an immediate provisional diagnosis in toxicology at the emergency department is very challenging, especially when the patient presents with altered mental status, because the clinical features of several toxidromes overlap.

diagnosis and treatment of theophylline overdose or in monitoring levels of theophylline to help ensure appropriate therapy.

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SUMMARY AND EXPLANATION OF TEST Theophylline (1,3-dimethylxanthine) is a naturally occurring compound with bronchodilator effects that is used in the treatment of asthma.1,2.

PRODUCT INFORMATION NUELIN SR TABLETS. COMPOSITION. Nuelin SR contains mg, mg or mg anhydrous theophylline (1,3- dimethyl xanthine, serum theophylline assays. Use in Pregnancy (Category A) Every theophylline overdose should be regarded as potentially fatal and all patients should be closely monitored.

Computer evaluation of the EMIT assays carbamazepine, ethosuximide, phenobarbital, phenytoin, quinidine and theophylline on the Gemsaec centrifugal fast analyser.

Unsuspected theophylline toxicity may be responsible for considerable hidden morbidity. AB - Slow-release theophylline preparations have been prescribed increasingly at the Brompton Hospital, and a serum theophylline assay is requested about once for every ten prescriptions.

Emit assay theophylline overdose
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Determination of theophylline concentration in serum by chemiluminescent immunoassay